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tecovirimat will boost the degree or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. Tecovirimat is actually a weak inhibitor of CYP2C8 and CYP2C19. Check for adverse effects if coadministered with delicate substrates of these enzymes.Allergic reactions for instance rash, angioedema, anaphylaxis, and Stevens